An extensive literature evaluate of studies in between 1995 and 2018 was performed using the electronic databases PubMed and EBSCO Host. Queries have been carried out working with the subsequent conditions: complete knee arthroplasty (TKA); cyclooxygenase-2 inhibitors; bracing; Bodily therapy; weight loss; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/