Participant eaten grapefruit or grapefruit items within three times before the first dose of study drug. Ubiquitin-connected proteins that regulate The steadiness of vital super enhancer-mediated proteins have also been documented to be involved in BET inhibitor resistance. As an example, BRD4 interacted with and was de-ubiquitinated by deubiquitinase DUB3. https://abbv-744-therapeutic-pote46891.yomoblog.com/38361199/abbv-744-in-combination-with-immunotherapy-an-overview