Gastrointestinal (GI): NSAIDs that block COX-1 action have correlations with GI complications because of the inhibition on the synthesis of gastroprotective agents like PGE2 along with other prostaglandins. This inhibition leads to diminished mucin creation by gastric epithelial cells, fewer bicarbonate secretion, and fewer epithelial mobile turnover, between other steps. https://josephm691hfh1.wikiconverse.com/user